Anthony T Nials Selected Research

1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amine

9/2009

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

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Anthony T Nials Research Topics

Disease

7	Asthma (Bronchial Asthma) 10/2018 - 11/2008
3	Inflammation (Inflammations) 10/2018 - 12/2012
3	Chronic Obstructive Pulmonary Disease (COPD) 12/2011 - 04/2011
3	Vomiting 04/2011 - 09/2009
2	Respiratory Hypersensitivity 01/2017 - 12/2012
2	Pneumonia (Pneumonitis) 12/2012 - 04/2011
2	Nausea 04/2011 - 09/2009
1	Eosinophilia 10/2018
1	Bronchial Spasm 10/2018
1	Pulmonary Edema 05/2015
1	Edema (Dropsy) 05/2015
1	Hyperplasia 12/2012
1	Airway Remodeling 12/2012
1	Respiratory Tract Diseases (Respiratory Tract Disease) 04/2011
1	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 04/2011
1	Pica (Geophagia) 09/2009

Drug/Important Bio-Agent (IBA)

4	Phosphodiesterase 4 InhibitorsIBA 12/2012 - 09/2009
3	OvalbuminIBA 01/2017 - 04/2011
3	AllergensIBA 05/2015 - 11/2008
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2017 - 05/2015
2	LipopolysaccharidesIBA 01/2017 - 04/2011
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2017 - 12/2012
2	6- ((3- ((dimethylamino)carbonyl)phenyl)sulfonyl)- 8- methyl- 4- ((3- methyloxyphenyl)amino)- 3- quinolinecarboxamideIBA 04/2011 - 04/2011
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2011 - 04/2011
2	EmeticsIBA 04/2011 - 09/2009
2	RoflumilastIBA 04/2011 - 09/2009
1	SteroidsIBA 10/2018
1	Environmental Pollutants (Pollutants, Environmental)IBA 10/2018
1	GlucocorticoidsIBA 10/2018
1	SmokeIBA 10/2018
1	CytokinesIBA 01/2017
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2017
1	AntigensIBA 03/2015
1	CollagenIBA 12/2012
1	GW 274150IBA 12/2012
1	Pharmaceutical PreparationsIBA 12/2012
1	Adrenergic Receptors (Adrenergic Receptor)IBA 12/2011
1	Bronchodilator Agents (Bronchodilators)IBA 12/2011
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 09/2009
1	AminesIBA 09/2009
1	PyransIBA 09/2009
1	RolipramIBA 09/2009
1	1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amineIBA 09/2009
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 09/2009
1	CilomilastIBA 09/2009

Therapy/Procedure

2	Therapeutics 10/2018 - 12/2012
1	Anesthesia 09/2009